| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2814711 | Gene | 2016 | 11 Pages |
Abstract
Although significant advances have been established in molecular biology of Oral squamous cell carcinoma (OSCC), innovative strategies are still required to further understand detailed molecular mechanisms. Using bioinformatic approach, we aim to explore the potential miRNA-mRNA pairs in cancer related inflammatory response and investigate their potential roles as signature miRNA and proteins in the signaling pathway. Firstly, the differentially expressed genes of OSCC were selected which then underwent gene ontology to identify genes engaged in inflammatory response and its regulation. Validated miRNAs were retrieved and miRNAs with complete complementarily with their targets were visualized for miRNA-mRNA regulatory network. Protein-protein interactions of inflammatory and its regulatory genes were analyzed for interacting genes involved in signaling pathway. Eight universal miRNAs were obtained for inflammation and its regulation. miRNA-19a/b showed significant influence in controlling inflammatory response in OSCC. Therefore, micronome on deregulated genes in inflammation identifies miRNA-mRNA pairs which have high potential to be targeted for diagnostic and treatment applications in OSCC.
Keywords
IL8STAT3FOSCXCL2OSCCNGSCRIPPIAnxa1CD44CCl4RELTLR2SDC1CD40CXCR4ICAM1CCR2C-C chemokine receptor type 2CXCL1chemokine (C-X-C motif) ligand 2TLR4CCR5IL6Akt1NOS2Ptgs2IL18HMOX1PIK3CACXCL5TGFB1TP73IL10CXCL9CXCL10CXCL11chemokine (C-X-C motif) ligand 9AIM2CSF1RTNFAIP3OGG1OLR1IL1RNCnr2ACVR1CXCL13CCL19FN1SphK1TFRCCCL20C-X-C motif chemokine 10BLNKNFKB1S100A12CEBPBnuclear factor of kappa light polypeptide gene enhancer in B-cells 1STRINGSPP1Colony stimulating factor 1 receptorELF3ADAM8SERPINA3GJA1IL4RmgllETS1CXCL3FBJ murine osteosarcoma viral oncogene homologtransforming growth factor, beta 1C-C chemokine receptor type 5Thbs1chemokine (C-C motif) ligand 4PTGS1v-rel avian reticuloendotheliosis viral oncogene homolog Achemokine (C-C motif) ligand 20CysLTR1Protein Protein InteractionB-Cell Linker8-oxoguanine DNA glycosylaseHIF1av-akt murine thymoma viral oncogene homolog 1Interleukin 1 receptor antagonistAnnexin A1Sphingosine kinase 1Interleukin 10Interleukin 18interleukin 6Interleukin 8secreted phosphoprotein 1thrombospondin 1Next generation sequencingcomplement component 3cluster of differentiation 40cluster of differentiation 44RelAhypoxia-inducible factor 1-alphaphosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alphafibronectin 1LynMonoglyceride lipasesignal transducer and activator of transcription 3Intercellular adhesion molecule 1MicroRNAMiRNAC-X-C chemokine receptor type 4nitric oxide synthase 2absent in melanoma 2prostaglandin E synthaseprostaglandin-endoperoxide synthase 2oral squamous cell carcinomatransferrin receptorinterleukin 4 receptorToll-like receptor 2Toll-like receptor 4cysteinyl leukotriene receptor 1cannabinoid receptor 2
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Authors
Ajay Francis Christopher, Mridula Gupta, Parveen Bansal,