| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2815759 | Gene | 2015 | 7 Pages |
•TGF-β/Smad2/3 signal pathway is regarded as a central regulator in various tumors.•The TGF-β/Smad2/3 signal pathway is activated in human brain glioma cells.•Inhibitor (SB203580) and siRNA against Smad2/3•TGF-β/Smad2/3 pathway plays a key role in U251 cell growth and metastasis.
TGF-β/Smad2/3 signal pathway is regarded as a central regulator in various tumors, but its roles in brain cancer therapy remain unknown. In this study, we identify that the TGF-β/Smad2/3 signal pathway is activated in human brain glioma cells; inhibitor (SB203580) and siRNA against Smad2/3 quickly inhibited the phosphorylation of Smad2 and 3, expression of its major downstream gene, Ki-67, arrested cells in the G2/M phase and induced apoptosis of cells. The findings suggest that TGF-β/Smad2/3 pathway plays a key role in U251 cell growth and metastasis, which suggests its potential role in the molecular therapy of brain cancer.
