| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2815892 | Gene | 2015 | 6 Pages |
•We assessed VEGF − 634G/C polymorphism and autoimmune diseases risk by meta-analysis.•VEGF − 634G/C polymorphism is linked to autoimmune diseases in Asian population.•The role of VEGF polymorphism in autoimmune diseases may be based on ethnicity.•This work is helpful to understanding the mechanism of autoimmune diseases.
The role of VEGF − 634G/C polymorphism has been involved in the investigations of susceptibility to autoimmune diseases, but the conclusion remains controversial. Here, we have performed a meta-analysis to clarify the relationship between them. All relevant articles updating to August 2013 were searched in PubMed and EMBASE. Crude odds ratios (ORs) with 95% confidence intervals (CIs) based on the available articles were calculated. A total of 24 independent studies associated with autoimmune disease were analyzed in our research. The results show that VEGF − 634G/C polymorphism was associated with susceptibility to autoimmune disease in Asian population (C vs. G: OR = 0.88, 95% CI: 0.80–0.96, P = 0.543; CC vs. GG: OR = 0.77, 95% CI: 0.63–0.93, P = 0.787; CC + GC vs. GG: OR = 0.80, 95% CI: 0.67–0.96, P = 0.080 by random effects model). Nevertheless, no significant associations were found in total population or in other stratified groups. In the current meta-analysis, we reveal a significant association between VEGF − 634G/C polymorphism and susceptibility to autoimmune diseases in Asian population.
