Article ID Journal Published Year Pages File Type
2816129 Gene 2014 6 Pages PDF
Abstract

•Variations in LAIR-1 genetic pathways are species difference and tissue specificity.•In vivo genetic interaction of human LAIR-1 with LAIR-2 rarely occurs.•Interactive fashion for LAIR-1 and LAIR-2 in vivo relies more on organ type.

Growing evidence suggests that defective expression or dysfunction of LAIR-1, a novel immunoinhibitory receptor for collagen, is closely associated with some autoimmune diseases, cancers, as well as viral infections. We analyzed the variation of LAIR-1 genetic pathways in murine versus human internal organs, including the lung and brain. The results showed that, under physiological conditions, LAIR-1 links more closely to the common genes in mouse than in human, which poses tissue specificity. It means that mice experimental data in relation to the role of LAIR-1 immune regulation may be overestimated when applied to assess human conditions. Moreover, we found that the in vivo interaction of LAIR-1 with LAIR-2 rarely occurs, implying that the species difference in LAIR-1 genetic pathways could not be primarily attributed to the existence of human LAIR-2. In summary, this study opens the door for insight into LAIR-1 functions inside the human body, and raises concern as to extrapolative credibility of the murine model in biomedical research.

Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Genetics
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