Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2816633 | Gene | 2014 | 5 Pages |
•Lymphocytes expressed the highest levels of LAMP-1 than LAMP-2.•Phagocytes expressed the highest levels of LAMP-2 than LAMP-1.•FD patients' phagocytes expressed more LAMP-2 than the controls' phagocytes.•LAMP-2 expression in phagocytes also diminished continuously over ERT.
This study investigated the potential relationship between the expression levels of lysosome-associated membrane proteins (LAMP) 1 and 2 and responses to enzyme replacement therapy (ERT) in the members of a single family with Fabry disease (FD). LAMP levels were assessed by flow cytometry in leukocytes from 17 FD patients who received an eight-month course of ERT course and 101 healthy individuals. We found that phagocytic cells from the FD patients had higher expression levels of both LAMP-1 and LAMP-2, relative to the levels in phagocytes from the healthy controls (p = 0.001). Furthermore, the LAMP-1 and LAMP-2 levels in phagocytes from the FD carriers continuously decreased with ERT administration to reach levels similar to those in healthy controls. We suggest that LAMP-1 and LAMP-2 could be used as additional markers with which to assess ERT effectiveness in FD.