Genes alternations with exposure time of environmental factors

•Genes are sensitive to exposure level and to exposure time of environmental factors.•Model and simulation show that disease risk depends on both exposure level and time.•Disease risk has a maximum depending on sets of exposure level and exposure time.

A theoretical model discussing the environmental factors (EFs) effect of exposure time on genes, which leads to human diseases, is presented using multi-logistic model. The advantages and limitations of this model are discussed in terms of its usefulness for simulating genetic samples. It has been shown that EFs affect genes with the same degree both at high exposure level, low exposure time and at low exposure level, high exposure time.

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