| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2817674 | Gene | 2012 | 4 Pages |
BackgroundMany microRNAs (miRNAs) exhibit altered expression levels in cancers, and they may be considered as valuable prognostic biomarkers for cancers. Here we aimed to summarize the recent advances in miR-210 involvement in human breast cancer and analyze the predicting role of miR-210 for survival.MethodsA meta-analysis was performed by searching PubMed, Cochrane Library, and Science Direct databases. Data were extracted from studies comparing survival in patients with breast cancer having higher expression of miR-210 with those having lower expression. Pooled hazard ratios (HRs) and 95% confidence intervals (CI) were calculated.ResultsA total of 511 cases of breast cancer were involved for this global meta-analysis. For post-operational survival, the HR of higher miR-210 expression in breast cancer tissue was 3.39 (95% CI: 2.04–5.63, P < 0.05), which could significantly predict poorer survival.ConclusionsHigh expression of miR-210 might predict poor survival in patients with breast cancer.
► 511 cases of breast cancer were included in this meta-analysis. ► The pooled hazard ratio was 3.39. ► High expression of miR-210 predicts poor survival.
