Regulation of gene transcription by the oncoprotein MYC

The proteins of the MYC/MAX/MAD network are central regulators of many key processes associated with basic cell physiology. These include the regulation of protein biosynthesis, energy metabolism, proliferation, and apoptosis. Molecularly the MYC/MAX/MAD network achieves these broad activities by controlling the expression of many target genes, which are primarily responsible for the diverse physiological consequences elicited by the network. The MYC proteins of the network possess oncogenic activity and their functional deregulation is associated with the majority of human tumors. Over the last years we have witnessed the accumulation of a considerable number of molecular observations that suggest many different biochemical means and tools by which MYC controls gene expression. We will summarize the more recent findings and discuss how these different building blocks might come together to explain how MYC regulates gene transcription. We note that despite the many molecular details known, we do not have an integrated view of how MYC uses the different tools, neither in a spatial nor in a temporal order.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (53 K)Download as PowerPoint slideHighlights► MYC controls up to 15% of all genes. ► MYC activates gene expression by recruiting multiple cofactors. ► A prime target of MYC is the C-terminal domain of polymerase II. ► MYC activates paused polymerase and promotes processivity.