| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2818473 | Gene | 2011 | 9 Pages |
Abstract
The Aotus nancymaae (owl monkey) is an important animal model in biomedical research, particularly for the preclinical evaluation of vaccine candidates against Plasmodium falciparum and Plasmodium vivax, which require a precisely typed major histocompatibility complex. The exon 2 from A. nancymaae MHC-DPA1 gene was characterised in order to infer its allelic diversity and evolutionary history. Aona-DPA1 shows no polymorphism and is related to other primate DPA alleles (including Catarrhini and Platyrrhini), constituting an ancient trans-specific and strongly supported lineage with different variability and selective patterns when compared to other primate-MHC-DPA1 lineages. A. nancymaae monkeys have thus a smaller MHC-DP polymorphism than MHC-DQ or MHC-DR.
Keywords
NWMPBRTSPAPCRELMHC class II moleculeGRMDSLACFELantigen-presenting cellsfixed effects likelihoodMolecular evolutionMaximum likelihoodSingle Likelihood Ancestor Countingmajor histocompatibility complexMHCAnimal modelmillion yearsOld World monkeysNew World monkeysneighbour joiningPARsParsimonyPlatyrrhini
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Authors
Carlos F. Suárez M., Manuel A. Patarroyo, Manuel E. Patarroyo,