Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2819086 | Gene | 2008 | 5 Pages |
Abstract
CovR/S is an important two component regulatory system, which regulates about 15% of the gene expression in Streptococcus pyogenes. The covR/S locus was identified as an operon generating an RNA transcript around 2.5-kb in size. In this study, we found the covR/S operon produced three RNA transcripts (around 2.5-, 1.0-, and 0.8-kb in size). Using RNA transcriptional terminator sequence prediction and transcriptional terminator analysis, we identified two atypical rho-independent terminator sequences downstream of the covR gene and showed these terminator sequences terminate RNA transcription efficiently. These results indicate that covR/S operon generates covR/S transcript and monocistronic covR transcripts.
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Genetics
Authors
Chuan Chiang-Ni, Chih-Cheng Tsou, Yee-Shin Lin, Woei-Jer Chuang, Ming-T. Lin, Ching-Chuan Liu, Jiunn-Jong Wu,