Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2819178 | Gene | 2008 | 6 Pages |
Abstract
Tbx2, a member of the T-box family of genes that encode developmentally important transcription factors, plays a critical role in development and has been linked to cancer. Here a 5′-flanking region of the human Tbx2 gene was cloned and characterized. While we identify a Sp1 element and a reverse CCAAT box to be essential for basal Tbx2 promoter activity, a physical interaction between Sp1 and NF-Y does not seem to be required for mediating their effect. Furthermore, our data reveal a downstream promoter element (DPE) in the Tbx2 promoter which significantly influences basal activity.
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Authors
Huajian Teng, M. Iqbal Parker, Sharon Prince,