| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2820119 | Gene | 2006 | 9 Pages |
Abstract
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a phosphatidylinositol phosphate phosphatase and is frequently inactivated in human cancers. The balance between phosphoinositide 3-kinase (PI3K) and PTEN determines PI(3,4,5)P3 levels. PI3K is regulated by a variety of intracellular and extracellular signals, but little is known about the regulation of PTEN. In this article, we review control of PTEN function by phosphorylation as well as by binding of lipid and protein partners.
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Authors
Arne Gericke, Mary Munson, Alonzo H. Ross,