Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2820479 | Gene Reports | 2016 | 8 Pages |
Abstract
MicroRNAs (miRNAs) are a class of small non-coding RNA molecules which regulate posttranscriptional events. Many studies have revealed that miRNAs have emerged as disease-suppressive molecules or oncomiRs by targeting disease oncogenes or suppressor genes. Therefore, miRNAs have become a hotspot in many researches. MiR-370 is located within the DLK1/DIO3 imprinting region on human chromosome 14. This region contains one of the largest miRNA clusters in the genome. Many miRNAs in this cluster including miR-370 have been reported to be involved in many diseases. The purpose of this review article is to summarize previous studies which have been published and have shown that miR-370 plays an important role in organ system diseases.
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Biochemistry, Genetics and Molecular Biology
Genetics
Authors
Jie Zhu, Bin Zhang, Wenfeng Song, Xie Zhang, Lei Wang, Bowei Yin, Fangfang Zhu, Chaohui Yu, Hong Li,