| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2820660 | Genomics | 2015 | 7 Pages |
•Yeast segregants with higher MAC showed a more dramatic shortening of the lag phase after ethanol exposure.•The short lag phase as acquired by ethanol training was more dramatically lost after recovery for the high MAC group.•There was a preferential association between MAC and traits linked with higher number of additive QTLs.
We studied the collective effects of single nucleotide polymorphisms (SNPs) on transgenerational inheritance in Caenorhabditis elegans recombinant inbred advanced intercross lines (RIAILs) and yeast segregants. We divided the RIAILs and segregants into two groups of high and low minor allele content (MAC). RIAILs with higher MAC needed less generations of benzaldehyde training to gain a stable olfactory imprint and showed a greater change from normal after benzaldehyde training. Yeast segregants with higher MAC showed a more dramatic shortening of the lag phase length after ethanol exposure. The short lag phase as acquired by ethanol training was more dramatically lost after recovery in ethanol free medium for the high MAC group. We also found a preferential association between MAC and traits linked with higher number of additive QTLs. These results suggest a role for the collective effects of SNPs in transgenerational inheritance, and may help explain human variations in disease susceptibility.
