Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2821475 | Genomics | 2006 | 5 Pages |
Abstract
Positional cloning of two recessive mutations of the mouse that cause polysyndactyly (dan and mdig—Chr 2) confirmed that the gene encoding MEGF7/LRP4, a member of the low-density lipoprotein receptor family, plays an essential role in the process of digit differentiation. Pathologies observed in the mutant mice provide insight into understanding the function(s) of LRP4 as a negative regulator of the Wnt–β-catenin signaling pathway and may help identify the genetic basis for common human disorders with similar phenotypes.
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Authors
Dominique Simon-Chazottes, Sylvie Tutois, Michael Kuehn, Martin Evans, Franck Bourgade, Sue Cook, Muriel T. Davisson, Jean-Louis Guénet,