Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2822094 | Genomics Data | 2015 | 4 Pages |
Abstract
The physiological function of the human DNA polymerase θ (pol θ) is still unclear despite its in vitro translesion synthesis capacity during DNA damage repair process. However this DNA polymerase is always present along the cell cycle in the absence of replication stress and DNA damage. Is there a different molecular function? We present the genomic data of replication timing in depleted pol θ cells (GSE49693) and in cells overexpressing pol θ (GSE53070) indicating that Pol θ holds a novel role in the absence of external stress as a critical determinant of the replication timing program in human cells.
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Genetics
Authors
Giuseppe Baldacci, Jean-Sebastien Hoffmann, Jean-Charles Cadoret,