Article ID Journal Published Year Pages File Type
2824478 Plasmid 2006 11 Pages PDF
Abstract

SXT is an integrating conjugative element (ICE) that was initially isolated from a 1992 Vibrio cholerae O139 clinical isolate from India. This ∼100-kb ICE encodes resistance to multiple antibiotics. SXT or closely related ICEs are now present in most clinical and some environmental V. cholerae isolates from Asia and Africa. SXT-related ICEs are not limited to V. cholerae. It is now clear that so-called IncJ elements such as R391 are closely related to SXT. More than 25 members of the SXT/R391 family of ICEs have now been identified in environmental and clinical isolates of diverse species of γ-proteobacteria worldwide. In this review, we discuss the diversity, evolution and biology of this family of ICEs.

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