| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2824580 | Trends in Genetics | 2016 | 4 Pages |
Abstract
A major challenge in genomics is to identify functional elements in the noncoding genome. Recently, pooled clustered regularly interspersed palindromic repeat (CRISPR) mutagenesis screens of noncoding regions have emerged as a novel method for finding elements that impact gene expression and phenotype/disease-relevant biological processes. Here we review and compare different approaches for high-throughput dissection of noncoding elements.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Genetics
Authors
Jason B. Wright, Neville E. Sanjana,