Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2824838 | Trends in Genetics | 2012 | 9 Pages |
Abstract
This review examines the proposition that the nucleosome, in addition to its role as a DNA packaging device, is a signaling module through which changing environmental and metabolic conditions can influence genomic functions. The role of enzyme-catalyzed post-translational modifications of the core histones is critically assessed, leading to the conclusion that they play varied, often crucial and sometimes causative roles in this signaling process.
Keywords
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Authors
Bryan M. Turner,