Article ID Journal Published Year Pages File Type
2824838 Trends in Genetics 2012 9 Pages PDF
Abstract

This review examines the proposition that the nucleosome, in addition to its role as a DNA packaging device, is a signaling module through which changing environmental and metabolic conditions can influence genomic functions. The role of enzyme-catalyzed post-translational modifications of the core histones is critically assessed, leading to the conclusion that they play varied, often crucial and sometimes causative roles in this signaling process.

Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Genetics
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