| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2825151 | Trends in Genetics | 2008 | 5 Pages |
Abstract
Trinucleotide repeats (TNRs) have been primarily connected to neurologic and neuromuscular diseases, with few specific TNRs linked with various tumors. Here we conduct a genome-wide analysis and show that TNRs are five times more prevalent in cancer-related human genes. Interestingly, we also find that cancer-related genes are significantly longer than other genes. Our results suggest that genes containing TNRs are more prone to mutagenesis. The database of TNR genes can be used as a list of candidate cancer-related genes.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Genetics
Authors
Yael Haberman, Ninette Amariglio, Gideon Rechavi, Eli Eisenberg,