| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2825235 | Trends in Genetics | 2007 | 4 Pages |
Abstract
Cancers are thought to originate in stem cells through the accumulation of multiple mutations. Some of these mutations result in a loss of heterozygosity (LOH). A recent report demonstrates that exposure of mouse embryonic stem cells to nontoxic amounts of mutagens triggers a marked increase in the frequency of LOH. Thus, mutagen induction of LOH in embryonic stem cells suggests a new pathway to account for the multiple homozygous mutations in human tumors. This induction could mimic early mutagenic events that generate cancers in human tissue stem cells.
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Authors
Jason H. Bielas, Ranga N. Venkatesan, Lawrence A. Loeb,