| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2825374 | Trends in Genetics | 2008 | 4 Pages |
Abstract
By analyzing the spacing of genes on chromosomes, we find that transcriptional and RNA-processing regulatory sequences outside coding regions leave footprints on the distribution of intergenic distances. Using analogies between genes on chromosomes and one-dimensional gases, we constructed a statistical null model. We used this to estimate typical upstream and downstream regulatory sequence sizes in various species. Deviations from this model reveal bi-directional transcriptional regulatory regions in Saccharomyces cerevisiae and bi-directional terminators in Escherichia coli.
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Authors
Rutger Hermsen, Pieter Rein ten Wolde, Sarah Teichmann,