| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2825473 | Trends in Genetics | 2007 | 4 Pages |
Abstract
Polyploid cells are a characteristic feature of certain human tissues, and notably many cancers. In a systematic genomic screen in yeast, Storchová and co-workers identified the genetic requirements of tetraploidy. Surprisingly, they showed that only three connected pathways are essential for the viability of tetraploid yeast cells. These data provide exciting new targets that might be essential specifically in polyploid cancer cells.
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Authors
Peter H. Thorpe, Sergio González-Barrera, Rodney Rothstein,