| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2827120 | Blood Cells, Molecules, and Diseases | 2015 | 7 Pages |
Abstract
MXD3 is a transcription factor that plays an important role in proliferation of human DAOY medulloblastoma cells. Here, we demonstrate that MXD3 is highly enriched in human precursor B acute lymphoblastic leukemia (preB ALL) samples compared to mobilized peripheral blood mononuclear cells, bone marrow, or hematopoietic stem cells from healthy donors. MXD3 knock-down in the preB ALL cell line Reh resulted in decreased cell numbers with no change in G0/G1, S or G2/M populations but increased apoptosis compared to control cells. Our results suggest that MXD3 is important for survival of Reh preB ALL cells, possibly as an anti-apoptotic factor.
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Authors
Gustavo A. Barisone, Noriko Satake, Carly Lewis, Connie Duong, Cathy Chen, Kit S. Lam, Jan Nolta, Elva Dίaz,