| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2827321 | Blood Cells, Molecules, and Diseases | 2013 | 7 Pages |
Abstract
Hematopoietic stem cells (HSC), which reside in the marrow of adult mammals and sustain hematopoiesis for the lifetime of the organism, are specified and generated during embryonic development. We are just beginning to understand how HSC develop from more primitive cells and the complexity of the signaling pathways involved. In this work, we review the role of two crucial pathways, Notch and Wnt, in the specification and development of HSC and their nascent microenvironment, the arterial vessels.
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Authors
Anna Bigas, Jordi Guiu, Leonor Gama-Norton,