| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2827640 | Blood Cells, Molecules, and Diseases | 2009 | 5 Pages |
Abstract
In this report we review the current knowledge of the interaction of RUNX1(AML1) with serine/threonine kinases, lysine and arginine methyltransferases, lysine acetyltransferases, and histone deacetylases. We also discuss the effect of RUNX1–ETO fusion gene on DNA methylation. RUNX1 post-transcriptional modification can affect its role in influencing differentiation and self-renewal of hematopoietic cells. The goal of these studies is to develop targets for improved leukemia therapy.
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Authors
Lan Wang, Gang Huang, Xinyang Zhao, Megan A. Hatlen, Ly Vu, Fan Liu, Stephen D. Nimer,