| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2828347 | Blood Cells, Molecules, and Diseases | 2006 | 4 Pages |
Abstract
The concentration of the complex between activated protein C and the protein C inhibitor reflects the degree of activation of blood coagulation. A sandwich method has been devised that measures the complex concentration in blood plasma. A key feature of the method is that the catching monoclonal antibody recognizes a complex-dependent neoepitope in PCI, which is a prerequisite, since the concentration of uncomplexed PCI is ≈104-fold higher than that of the complex. In patients with atherosclerotic disease, those with aortic aneurysms exhibit a three-fold increase in complex concentration compared to that of normal subjects.
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Authors
J. Stenflo, M. Kjellberg, K. Strandberg, P.J. Svensson, T. Kölbel, B. Lindblad,