Article ID Journal Published Year Pages File Type
2828348 Blood Cells, Molecules, and Diseases 2006 9 Pages PDF
Abstract

Any vascular injury triggers the burst-like release of the trypsin-like serine proteinase α-thrombin. Thrombin, the main executioner of the coagulation cascade, exhibits procoagulant as well as anticoagulant and antifibrinolytic properties, very specifically interacting with a number of protein substrates, receptors, cofactors, inhibitors, carbohydrates, and modulators. A large number of crystal structures of α-thrombin have shown that the thrombin surface can be subdivided into several functional regions, which recognize different substrates, inhibitors, and mediators with high specificity.

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