Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2828500 | Journal of Structural Biology | 2014 | 5 Pages |
Abstract
Net-negatively-charged heterospecific A:B:C collagen peptide heterotrimers were designed using an automated computational approach. The design algorithm considers both target stability and the energy gap between the target states and misfolded competing states. Structural characterization indicates the net-negative charge balance on the new designs enhances the specificity of the target state at the expense of its stability.
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Authors
Avanish S. Parmar, Sohail Zahid, Sandeep V. Belure, Robert Young, Nida Hasan, Vikas Nanda,