Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2828609 | Journal of Structural Biology | 2012 | 9 Pages |
Abstract
In conclusion, the structural data define a binding pattern for the recognition of sulfated molecules that can modulate the role of ECP in innate immunity. The results reveal the structural basis for the high affinity of ECP for glycosaminoglycans and can assist in structure-based drug design of inhibitors of the protein cytotoxicity to host tissues during inflammation.
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Authors
Ester Boix, David Pulido, Mohammed Moussaoui, M. Victòria Nogués, Silvia Russi,