Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2829374 | Journal of Structural Biology | 2007 | 11 Pages |
Abstract
Oncoprotein 18/stathmin (stathmin) is a phosphorylation-controlled key regulator of microtubule dynamics. In recent years, substantial efforts were undertaken to characterize the complex formed between tubulin and the intrinsically disordered stathmin molecule. Here, I summarize and illustrate the current structural and thermodynamic studies on the tubulin–stathmin interaction. Based on these and on functional information I formulate an updated molecular mechanism on how tubulin-binding by stathmin regulates microtubule dynamics.
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Authors
Michel O. Steinmetz,