The Haemonchus contortus UNC-49B subunit possesses the residues required for GABA sensitivity in homomeric and heteromeric channels

Article ID	Journal	Published Year	Pages	File Type
2829917	Molecular and Biochemical Parasitology	2011	8 Pages	PDF

Abstract

âº Residues important for GABAA receptor sensitivity are largely conserved between parasitic nematodes and mammals. âº Residues affecting GABA sensitivity were found only on the Hco-UNC-49B subunit. âº Met170 in the H. contortus UNC-49 receptor is associated with slightly higher GABA sensitivity.

Keywords

Haemonchus contortus MS-222 nAChR cRNA 5-HT3 LGIC AChBP copy RNA Electrophysiology Structure-function acetylcholine binding protein Ligand-gated ion channels nicotinic acetylcholine receptor GABA receptors