Mice lacking SÎ¼ tandem repeats maintain RNA polymerase patterns but exhibit histone modification pattern shifts linked to class switch site locations

Article ID	Journal	Published Year	Pages	File Type
2831211	Molecular Immunology	2012	8 Pages	PDF

Abstract

âº Histone H3 acetylation and trimethylation mark CSR accessible regions in B cells. âº SÎ¼ histone H3 marks depend on flanking but not underlying DNA sequences. âº Histone H3 dimethylation marks match with downstream boundaries of SÎ¼ CSR. âº Increases in RNAPII loading in the EÎ¼/IÎ¼ region are linked to initiation of CSR. âº Sequences just upstream of the SÎ¼ tandem repeats control SÎ¼ RNAPII loading.

Keywords

CSR S region PST RNAPII Activation-induced cytidine deaminase acH3 Histone H3 acetylation RNA polymerase II GLT RNA polymerase Histone modification chromatin immunoprecipitation class switch recombination Switch class switching Germline transcript switch region wild type CHiP AID