| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2831290 | Molecular Immunology | 2011 | 8 Pages |
Abstract
⺠Effect of the antibody format on their specificity to antigens was investigated. ⺠The reducing of format antibody from full-scale MAb to scFv resulted in developing of polyspecific properties. ⺠Reverse construction of full-size MAb from scFv base followed to specificity and affinity improvement. ⺠Specificity and affinity properties of antibodies were not determined by the primary source of constant antibody domain. ⺠ScFv within a phage particle in comparison with soluble scFv possess a greater specificity to the antigen.
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Authors
A.O. Shepelyakovskaya, A.G. Laman, A.V. Lomonosova, K.K. Fursova, G.V. Savinov, Yu.V. Vertiev, F.A. Brovko, E.V. Grishin,