Article ID Journal Published Year Pages File Type
2831672 Molecular Immunology 2011 5 Pages PDF
Abstract

B cells and antibodies are important elements of acquired humoral immunity in the fight against various pathogens, and signals through the B cell receptor (BCR) are crucial for the development, activation and differentiation of B cells. Our laboratory has focused on understanding the molecular mechanisms of BCR-mediated signaling cascades that regulate these processes in B cells. In this review, I will briefly present our studies that have clarified the molecular components of signaling cascades, mainly focusing on data using DT40 B cells and their genetic variants.

Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Molecular Biology
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