Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2832143 | Molecular Immunology | 2008 | 7 Pages |
Abstract
The current study indicates disturbances in the peripheral B cell pool in juvenile rheumatoid arthritis. The peripheral blood B cell pool of JRA patients did show molecular changes in the kappa light chain repertoire which, in part, could be a sequel of secondary V(D)J-recombination and of a molecular bias during immunoglobulin rearrangement in the bone marrow. Thus, B cell tolerance might be broken by more than one pathogenic mechanism.
Keywords
JIAJRAterminal deoxynucleotide transferaseRAGMTXTdTNSAIDSHMJuvenile idiopathic arthritisJuvenile rheumatoid arthritisRheumatoid arthritissomatic hypermutationAutoantibodyHumanimmunoglobulin gene rearrangementautoimmunityNon-steroidal anti-inflammatory drugsB cellsRecombination Activating GeneSystemic lupus erythematosusSLEMethotrexate
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Authors
Henner Morbach, Petra Richl, Claudius Faber, Sunit K. Singh, Hermann J. Girschick,