Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2832546 | Molecular Immunology | 2007 | 6 Pages |
Abstract
A substantial proportion of patients with systemic lupus erythematosus (SLE) develop renal inflammatory disease, so-called lupus nephritis (LN). LN is a severe complication of SLE which is strongly associated with the presence of autoantibodies against C1q, the first component of the complement system, and other self-antigens (i.e. against DNA and nucleosomes) as well. In this review, the authors focus on anti-C1q autoantibodies and interpret the available data in order to explain how LN may develop and how anti-C1q autoantibodies contribute to its pathogenesis.
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Authors
Roelof Flierman, Mohamed R. Daha,