Gating pluripotency via nuclear pores

•Dynamic nuclear transport in pluripotency maintenance and cell differentiation.•Trafficking of pluripotency factors through nuclear pores.•Nuclear pore dysfunction in human diseases and aging is discussed.•Cell fate and nuclear pore activity.

In recent years, growing evidence has pointed to the interesting idea that pluripotency might be regulated by a nuclear-pore-coordinated network that controls the level of pluripotency factors in the nucleus. A thorough understanding of this process might improve our comprehension of cell pluripotency and differentiation during embryogenesis, as well as aiding the development of novel models for studying human diseases.