| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2838645 | Trends in Molecular Medicine | 2014 | 12 Pages |
•The unique miRNA-based signatures distinguish healthy controls from cancer cases with high sensitivity and specificity.•Differential expression pattern of miRNAs in various malignancies varies with smoking status of individuals.•Smoking mediates its impact by modulating tumor-suppressive miRNAs during neoplastic transformation and oncogenic miRNAs at later stages of cancer.•miRNAs are probably involved in smoking-induced modulation of signaling cascades in various cancers.
MicroRNAs (miRNAs) are post-transcriptional gene regulators that are differentially expressed in several pathophysiological conditions including cancer. They impact the disease course by modulating an array of putative target gene(s). Interestingly, there is a strong correlation between the various miRNAs target(s) and the smoking-regulated genes in cancer. This review article provides an insight into the current status of smoking-induced miRNAs and their genetic/epigenetic regulation in smoking-associated cancers, with a major focus on lung cancer (LC). Furthermore, it discusses the role of miRNAs in smoking-mediated oncogenic events in cancer and explores the diagnostic/prognostic potential of miRNA-based biomarkers and their efficacy as therapeutic targets.
