Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2839449 | Trends in Molecular Medicine | 2006 | 5 Pages |
Abstract
Myelin inhibitory ligands of the Nogo-66 receptor (NgR1) limit axon regeneration in the adult CNS. Recent findings have identified additional co-receptors (functional homologues) of the trimeric NgR1 complex, post-translational modifications of the co-receptors within the cell membrane and novel Ca2+-dependent cytoplasmic-protein phosphorylation mechanisms. Such unique signalling pathways provide the potential to transduce myelin-derived growth inhibitory signals to the axonal cytoskeleton, and have been areas of intense investigation in recent years. Here, we summarize current understanding of the molecular basis of myelin-derived axon-growth inhibition in the CNS.
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Authors
Jan M. Schwab, Sagun K. Tuli, Vieri Failli,