Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2840003 | Clínica e Investigación en Arteriosclerosis | 2010 | 20 Pages |
Abstract
Special emphasis has been placed on the use of mice as an experimental animal model in this field, since their use has unveiled the contribution of dietary modifications on plasma homocysteine levels. These findings, together with the generation of genetically-modified mice as models of hyperhomocysteinemia, are allowing rapid progress to be made in the characterization of the in vivo molecular mechanisms of homocysteine action. Crosses among these genetically-modified mice and others with different deleted genes will increase knowledge of the influence of the combination of several risk factors on pathological development. In these models, research into new environmental or pharmacological factors may yield results that could explain epidemiological findings in humans and help in the design of new treatments for specific clinical settings.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Physiology
Authors
Mario Nuño-Ayala, Ricardo Carnicer, Mario Alberto Guzmán, Natalia Guillén, MarÃa Ángeles Navarro, Carmen Arnal, Jesús Osada,