| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2840057 | Clínica e Investigación en Arteriosclerosis | 2008 | 7 Pages |
Abstract
We have demonstrated that the PUFAs n-3 EPA and DHA down-regulate NPC1L1 mRNA expression in vitro. In addition, PUFA also down-regulate NPC1L1 protein expression in enterocyte membranes. LXR and RXR activation induced a similar repression effect. The lipid lowering effect of n-3 PUFA could be mediated in part by their action at the NPC1L1 gene level.
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Authors
Adriana Álvaro, Roser Rosales, LluÃs Masana, Joan Carles Vallvé,