Sobreexpresión génica de citocinas proinflamatorias en macrófagos de sujetos con hipercolesterolemia familiar y xantomas tendinosos

The FH subjects with TX (FH TX+) showed a tendency to over-express IL-8 gene after 18 h of incubation with oxLDL, while FH subjects without TX (FH TX-) tended to overexpress TNF-α gene after 1 h of incubation. CXCL3 gene was significantly over-expressed at all incubation times with oxLDL in FH TX+ group. Furthermore, a positive correlation was found between CXCL3 gene expression and Achilles tendon size, being maximum at 3h of treatment with oxLDL (R = 0.782; p = 0.008). These results would suggest that CXCL3 could play an important role in the ethiology of xanthomas and could be considered as a possible predictor marker of these lipid deposits.