| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2842352 | Journal of Physiology-Paris | 2012 | 11 Pages |
Abstract
⺠Mutations in CaV2.1 Ca2+ channels cause familial hemiplegic migraine type 1 (FHM1). ⺠CaV2.1 channels with the human FHM1 mutations activate at more hyperpolarizing potentials. ⺠FHM1 generates a gain-of-function in synaptic transmission, affecting also synaptic plasticity. ⺠FHM1 increases the susceptibility for cortical spreading depression (CSD).
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Authors
Osvaldo D. Uchitel, Carlota González Inchauspe, Francisco J. Urbano, Mariano N. Di Guilmi,