Linking molecular motors to Alzheimer’s disease

It is currently thought that Alzheimer’s disease develops due to aberrant generation of amyloid-β peptides. However, the mechanisms underlying the aberrant generation of amyloid-β peptides remain unknown. An emerging concept suggests that impaired axonal transport may play a pivotal role in the aberrant generation of amyloid-β peptides. Here we review and discuss advances in understanding AD with the primary focus on the possible role of molecular motors and axonal transport in its pathogenesis.