Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2843926 | Physiology & Behavior | 2016 | 7 Pages |
Abstract
These data suggest that PIO may not be useful for reducing the abuse liability of OXY. These data were obtained with a sample of nondependent opioid users and therefore may not be applicable to dependent populations or to other opioids. Although PIO failed to alter the abuse liability of OXY, the interaction between glia and opioid receptors is not well understood so the possibility remains that medications that interact with glia in other ways may show more promise.
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Authors
Jermaine D. Jones, Maria A. Sullivan, Jeanne M. Manubay, Shanthi Mogali, Verena E. Metz, Roberto Ciccocioppo, Sandra D. Comer,