Article ID Journal Published Year Pages File Type
2847196 Respiratory Physiology & Neurobiology 2012 8 Pages PDF
Abstract

We have tested the hypothesis that high mass loading effects and obstructive sleep apnea (OSA) constrain the ventilatory response to exercise in morbidly obese subjects as compared to their counterparts without OSA. Fifteen obese patients with (8) and without OSA and 12 lean healthy subjects performed incremental cycle exercise. The functional evaluation included ventilation, oxygen uptake, carbon dioxide production, end-expiratory-lung-volumes (EELV), inspiratory capacity, heart rate, dyspnea and leg effort (by a modified Borg scale). Changes in ventilation and dyspnea per unit changes in work rate and metabolic variables were similar in the three groups. Breathing pattern and heart rate increased from rest to peak exercise similarly in the three groups. Leg effort was the prevailing symptom for stopping exercise in most subjects. In conclusion, OSA does not limit exercise capacity in morbidly obese subjects. Ventilation contributes to exertional dyspnea similarly as in lean subjects and in obese patients regardless of OSA.

► Fifteen obese patients with (8) and without OSA and 12 lean healthy subjects underwent incremental cycle exercise. ► Changes in ventilation and dyspnea per unit changes in work rate and metabolic variables were similar in the three groups below and above anaerobic threshold. ► OSA does not limit exercise capacity in morbidly obese subjects.

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