Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2847206 | Respiratory Physiology & Neurobiology | 2013 | 9 Pages |
Obesity affects airway diameter and tidal ventilation pattern, which could perturb smooth muscle function. The objective was to assess the pathophysiology of airway hyperresponsiveness in obesity while controlling for gastro-oesophageal reflux disease.Obese women (n = 118, mean ± SD BMI 46.1 ± 6.8 kg/m−2) underwent pulmonary function testing (including tidal ventilation monitoring and methacholine challenge) and oesogastro-duodenal fibroscopy.Fifty-seven women (48%, 95% CI: 39–57%) exhibited hyperresponsiveness (dose–response slope ≥2.39% decrease/μmol) that was independently and positively correlated with predicted % FRC, Raw0.5 and negatively correlated with sigh frequency during tidal ventilation. Obese women had an increased breathing frequency but a similar sigh frequency than healthy lean women (n = 30). Twenty-two obese women (19%, 95% CI: 12–26%) were classified as asthmatics (hyperresponsiveness and suggestive symptoms) without confounding effect of gastro-oesophageal reflux disease.In conclusion, in women referred for bariatric surgery, unloading of bronchial smooth muscle (reduced airway calibre and sigh frequency) is associated with hyperresponsiveness.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Low frequency of sighs is associated with hyperresponsiveness in severely obese women. ► Reduced airway calibre is associated with hyperresponsiveness in severely obese women. ► Obese women fulfil standard criteria for asthma.