Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2863516 | The American Journal of the Medical Sciences | 2014 | 9 Pages |
Abstract
The association between testosterone and buccal TL supports gonadal maturation as a developmentally sensitive biomarker of aging within youth. As stress levels of testosterone were significantly associated with buccal TL, these findings are consistent with the growing literature linking stress exposure and accelerated maturation. The lack of association of diurnal testosterone or morning basal levels with buccal TL bolsters the notion of a shared stress-related maturational mechanism between cellular stress and the hypothalamic pituitary gonadal axis. These data provide novel evidence supporting the interaction of aging, physiologic stress and cellular processes as an underlying mechanism linking negative health outcomes and early life stress.
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Authors
Stacy S. MD, PhD, Andrew BA, Zoë H. PhD, Michael BS, Kyle BA, Elizabeth A. PhD, Jenny MS, Emily MS, Katherine P. PhD,