Elevated Adipose Triglyceride Lipase in Newly Diagnosed Type 2 Diabetes Mellitus With Hypertension

Plasma ATGL levels significantly increased in patients with T2DM and hypertension compared with those with T2DM (78.3 ± 23.4 versus 65.1 ± 22.8 μg/L, P < 0.01). No gender differences were found among plasma ATGL levels. Furthermore, they found that the plasma ATGL level was positively correlated with total cholesterol (r = 0.17, P < 0.05) and high-density lipoprotein C (r = 0.16, P < 0.05) in simple regression analysis of pooled data, whereas, in multiple stepwise regression analysis, diastolic blood pressure, total cholesterol and homeostasis model assessment of insulin resistance were independently related factors with plasma ATGL levels (Y = −13.662 + 0.343 × waist + 0.268 × diastolic blood pressure + 0.053 × 2hPin + 0.966 × homeostasis model assessment of insulin resistance). This work indicates the potential link of ATGL with the pathogenesis of insulin resistance and T2DM.